Abstract
Background: One-pot synthesis of new and biologically important betulinic acid derivatives has been designed and efficiently achieved in this work. Methods: The utilization of the carboxylic and hydroxyl moieties of betulinic acid has resulted in the development of a one-pot strategy towards the synthesis of some target compounds. Results: One-pot synthesis of new betulinic acid derivatives 3-9 has been achieved in moderate to high yields by way of esterification of the carboxylic functionality with a variety of alkylating agents. These were fully characterized by spectroscopic techniques. Conclusion: The synthesized new derivatives of betulinic acid were screened for their cytotoxic effect against human pancreatic cancer cells.
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