Abstract
α-Aminonitriles with a mono- or unsubstituted amino group as well as α-(alkylideneamino)nitriles can be employed as easily accessible α-aminocarbanion equivalents. Their α-deprotonation yields stabilized carbanions, which undergo smooth 1,4-addition to α,β-unsaturated carbonyl compounds. The resulting δ-keto-α-aminonitriles can be reductively cyclized to form polysubstituted pyrrolidines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
