One-Pot Synthesis of Isoindolin-1-ones with Thiamine Hydrochloride (VB1) as a Catalyst and Their Inhibitory Activity Against Cancer Cell Lines

Abstract

ABSTRACTA simple, highly efficient and green three-component condensation for synthesis of 2-substituted-3-(2-oxoalkyl)isoindolin-1-one derivatives from phthalaldehydic acid, primary amine, and ketone in the presence thiamine hydrochloride (VB1) as catalyst in water has been developed. Their activities have also shown inhibition activity against HeLa, A549, and Hep2 cancer cell lines. The results showed that some synthesized isoindolin-1-one derivatives have exhibited cytotoxic activity on HeLa, A549, and Hep-2 cancer cell lines at µg/mL concentrations.