Abstract

An efficient, base-promoted, one-pot, metal-free, open-flask synthesis of diverse, functionally enriched benzo[b]fluoren-11-ones has been discovered, and wide applicability of this exceptionally simple protocol with green flavors has been scoped. This synthesis proceeds via an unanticipated, tandem, double-aldol condensation between in situ-generated 1-indanone dianions and o-bis-ynones to furnish benzo[b]fluoren-11-ones harboring as many as six variegated substituents on their tetracyclic framework. This methodology has also been amplified to access heterocyclic analogues 2- and 4-azabenzo[b]fluorenones of benzo[b]fluoren-11-ones and extended to mixed linear-angular annulated pentacyclic dibenzo[a,h]fluoren-13-one.

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