One pot synthesis of carboxylic acid, ester, and amide derivatives from iodoarenes in aqueous solubilized systems using sodium oleate as surfactant at room temperature

Abstract

Palladium acetate [Pd(OAc)2] catalyzed reaction of aryl iodide utilizing sodium oleate as surfactant was demonstrated in water under ambient temperature and carbon monoxide pressure. Aryl carboxylic acid with different electron withdrawing and donating substituents, and multi-substituted acid derivatives were synthesized in good to excellent isolated yields. Notably, this protocol was also applicable for one pot synthesis of various amide and ester derivatives. Several drug molecules such as niacin, and mefenamic acid alike compound were also obtained in good, isolated yields.