Abstract
A simple and efficient method has been developed for the synthesis of benzo[b]thiophenes and naphtho[2,1-b]thiophenes from aryl thiols and α-halo ketones by using an acid- and a base-supported reagent system, Na 2 CO 3 /SiO 2 -PPA/SiO 2 . Reaction of α-halo ketones with aryl thiols is promoted by Na 2 CO 3 /SiO 2 to afford α-phenylthio ketones, which cyclizes in the presence of PPA/SiO 2 to give the corresponding arylthiophenes in one-pot.
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