One-pot synthesis of aryl oxime analogues from methyl arenes using NBS and hydroxyl amine hydrochloride

Abstract

The one-pot synthesis of aryl oximes is reported by the reaction of methyl arenes with NBS using hydroxyl amine hydrochloride. The direct conversion of methyl group into oxime group has been achieved under mild reaction conditions in the presence of sensitive functional groups including chloro, bromo, cyano, hydroxy, fluoro, dioxaborolane, esters, and trifluoro methyl substituents with excellent yields. The simple experimental procedure and easy purification make this protocol advantageous.