One-pot synthesis of aryl(hetaryl)-thiazolylphthalazine-1,4-diones via a multicomponent approach

Abstract

An expeditious one-pot synthesis has been developed to obtain aryl(hetaryl)-substituted thiazolylphthalazine-1,4-diones via multicomponent approach. Reaction of phenacyl bromides with thiosemicarbazide and phthalic anhydride afforded arylthiazolylphthalazine-1,4-diones. Reaction of 3-(2-bromoacetyl)coumarins with thiosemicarbazide and phthalic anhydride afforded hetaryl-containing 2-thiazolylphthalazine-1,4-diones under the same reaction conditions in excellent yields. The structures of all the synthesized compounds were confirmed by their analytical and spectral data. Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (4), pp 586-590 http://link.springer.com/article/10.1007/s10593-013-1285-2