Abstract
A simple and efficient method for one-pot synthesis of lophine derivatives (2,4,5-trisubstituted imidazoles) by using the benzyltriphenylphosphonium chloride (BTPPC), as a catalyst, under solvent-free conditions is described. BTPPC is an available and inexpensive catalyst; also, it can be easily supplied. This procedure led to the corresponding 2,4,5-trisubstituted imidazoles products in high yields. KEY WORDS : Lophine derivatives, BTPPC, Solvent-free, One-pot synthesis, Multi component synthesis Bull. Chem. Soc. Ethiop. 2017 , 31(1), 177-184. DOI: http://dx.doi.org/10.4314/bcse.v31i1.16
Highlights
Imidazole derivatives are an important class of heterocycles because of their applications in chemical processes and pharmaceuticals [1]
We have reported the one-pot synthesis of dihydropyrimidinones/thiones under solvent-free conditions using benzyltriphenylphosphonium chloride (BTPPC) as a catalyst [31]
We describe an efficient and practical route for the synthesis of lophine derivatives under solvent free conditions using BTPPC as catalyst (Scheme 1)
Summary
Imidazole derivatives are an important class of heterocycles because of their applications in chemical processes and pharmaceuticals [1]. Several methods such as the hetero-Cope rearrangement [3] and four-component condensation [4] for the synthesis of trisubstituted imidazoles are reported. Some of the methods are efficient from the synthetic chemist’s points, many of the synthetic protocols for imidazoles reported above suffer from one or more disadvantages, such as harsh reaction conditions, poor yields, and prolonged reaction time, use of hazardous and often expensive acid catalysts. We have reported the one-pot synthesis of dihydropyrimidinones/thiones under solvent-free conditions using BTPPC as a catalyst [31].
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