One-Pot Synthesis of 1,2,3-Triarylindoles through Cascade Reactions Using Calcium Carbide, Iodoarenes, and Aromatic Amines.

Abstract

An efficient method for the construction of 1,2,3-triarylindoles through one-pot multicomponent reactions using calcium carbide, 3 mol of iodoarenes, and aromatic amines as starting materials was described. A series of target products were obtained by the simultaneous formation of five bonds in one step. The main advantages for this protocol are the use of a convenient alkyne source, wide scope of substrates, and simple workup procedure. The method can be extended to the gram scale.