Abstract
This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite. The Ag-β-CD composite was synthesized via a hydrothermal route, which resulted in a high product yield. Morphological and spectral characterizations of the Ag-β-CD composite were carried out. The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The Ag-β-CD modified electrode displayed excellent specificity towards the electro-oxidation of ciprofloxacin. Further, the sensor gave the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5. A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation. The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples. High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
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