Abstract

The synthesis of some new �-amino phosphonates ( 4a-j) was accomplished by one pot reaction of equimolar quantities of 2-amino-4-chloro-5-nitro phenol ( 1), aromatic aldehydes ( 2a-j) and diethyl / dimethylphosphite ( 3) in dry tetrahydrofuran at reflux condition via Kabachnik - fields reaction in high yields. All the synthesized compounds were characterised by IR, 1 H, 13 C, 31 P NMR and examined for their antimicrobial activity and found to possess good activity .

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