Abstract
The simple pseudo four-component reaction of 2,7-naphthalenediol, tow molecules of aldehydes and ammonum carboxylates to produce a series of N-acylated and non-acylated highly substituted piperidine derivatives has been carried out in the presence of choline chloride/urea at 80 °C. One-pot reaction, high efficiency, appropriate reaction time, and easy purification of products by simple recrystallization are some of the considerable advantages of this procedure. The produced highly substituted piperidine derivatives were screened for their antioxidant property. The results indicated that the highly substituted piperidine derivative 4h had higher antioxidant properties.
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