Abstract
Abstractmagnified imageStoichiometric reaction of 2‐aminopyrimidine with formaldehyde in the presence of formic acid catalyst in water gave N,N′‐bis(2‐pyrimidinyl)methanediamine (5). Subsequent cyclocondensation of 5 with glyoxal in alcohol (MeOH, EtOH, PrOH and i‐PrOH) under reflux conditions led to the formation of the corresponding 4,5‐dialkoxy‐1,3‐bis(2‐pyrimidinyl)imidazolidines (6a‐d). 4,5‐Dihydroxy‐1,3‐bis(2‐pyrimidinyl) imidazolidine (6e) was obtained when the reaction was carried out in acetonitrile. Based on 1H NMR analysis, it was found that the trans‐dialkoxyimidazolidines (6) were selectively obtained in these cyclocondensation reactions.
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