One-Pot, Sequential Four-Component Synthesis of Thiazepine Derivatives

Abstract

A one-pot, sequential, four-component procedure for the synthesis of thiazepines by the reaction of primary amines, 1,3-dicarbonyl compounds, aryl isothiocyanates, and chloroacetyl chloride at room temperature is described. Advantages of this protocol include ease of handling, regioselectivity, the absence of a metal catalyst, and moderate yields.