Abstract
Synthesis of triazole linked macrocycles grafted with glyco-pyrrolidine/pyrrolizidine/thiazolidine/indolizine has been accomplished by one-pot sequential Huisgen cycloaddition and intramolecular azomethine ylide cycloaddition. The reaction involves the simultaneous formation of five bonds in one-pot to construct complex chiral macrocycles from the easily available starting materials. The structures of the macrocycles were confirmed by spectroscopic methods and X-ray crystallographic analysis.
Published Version
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