ONE POT PREPARATIONS N,N'-ALKYLIDENE BISAMIDE DERIVATIVES CATALYZED BY NANO-TiCL4.SiO2 WITH ANTIMICROBIAL STUDIES OF SOME PRODUCTS

Abstract

ABSTRACT Nano-TiCl 4 .SiO 2 has been introduced to be an extremely efficient catalyst for the preparation of N,N’ -alkylidene bisamides from various aldehydes and amides under mild conditions. We synthesized this solid Lewis acid catalyst by the reaction of nano-SiO 2 and TiCl 4 . The processor was simple and environmentally benign with high to excellent yields. Our method has the advantages of high yields, simple methodology, and easy work-up. The antimicrobial and antifungal activities of some of the synthetic compounds were determined by broth microdilution methods as recommended by Clinical Laboratory Standard Institute. Further studies still needed to investigate the other biological activities of the compounds.Keywords: Nano-TiCl 4 .SiO 2 , Heterogeneous catalyst, N,N’ -Alkylidene bisamides, Antifungal, Antibacterial. e-mails: l.zamani2008@gmail.com INTRODUCTION Amide and bisamide compounds are main part of many peptidomimetic 1 (and they play a major role in the expansion and composition of biological and pharmacological systems. They are of considerable interest in the synthesis of pharmacological materials such as peptidomimetic compounds