Abstract
A highly efficient and simple procedure for the preparation of N,N'-alkylidene bisamides via one-pot threecomponent condensation reaction of phenyl acetylene/1-Hexyne, aromatic aldehyde and benzamide/acetamide in the presence of catalytic amount of silica supported magnesium chloride (SiO2-MgCl2) under thermal solvent-free conditions is described. All of the reactions proceeded in high yields and in relatively short reaction times. Keywords: Amide, Heterogeneous catalyst, N, N'-alkylidene bisamide, Silica Supported Magnesium Chloride (SiO2-MgCl2), aldehydes, alkyne, purification, pharmacological, oxazine, bisamides
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