Abstract
A new one-pot and efficient three-component condensation of aldehyde, ketones, and amines in the presence of MgO/ZrO2 as an inexpensive and effective catalyst for the synthesis of beta-amino carbonyl compounds by Mannich reaction is described. The present methodology offers several advantages, such as good yields, Short reaction times and a recyclable catalyst with a very easy work up.
Highlights
The synthesis of natural molecules, pharmaceuticals and other nitrogenous biologically active compounds has long been a significant branch of organic synthesis
The products of Mannich reaction are mainly β -amino carbonyl compounds and its derivatives that are used for the synthesis of amino alcohols, peptides, and lactams and as precursors to optically active amino acids
They often suffer from the drawbacks of long reaction times and harsh reaction conditions, toxicity and difficulty in product separation, which limit its use in the synthesis of complex molecules.Yarahmadi et al (Hamid Reza Shaterian, 298-313) have synthesized β–amido ketones and esters in four-component condensation reaction using ferric hydrogensulfate as effective and reusable catalyst.Trissa Joseph et al (Suman Sahoo, 2006) have synthesized β-amino carbonyl compounds by using Bronsted ionic liquids as a solvent and catalyst
Summary
The synthesis of natural molecules, pharmaceuticals and other nitrogenous biologically active compounds has long been a significant branch of organic synthesis. Multi-component reactions (MCRs) are important for the achievement of high levels of brevity and diversity They allow more than two simple and flexible building blocks to be combined in practical, time-saving one-pot operations, giving rise to complex structures by simultaneous formation of two or more bonds, according to the domino principle. They often suffer from the drawbacks of long reaction times and harsh reaction conditions, toxicity and difficulty in product separation, which limit its use in the synthesis of complex molecules.Yarahmadi et al (Hamid Reza Shaterian, 298-313) have synthesized β–amido ketones and esters in four-component condensation reaction using ferric hydrogensulfate as effective and reusable catalyst.Trissa Joseph et al (Suman Sahoo, 2006) have synthesized β-amino carbonyl compounds by using Bronsted ionic liquids as a solvent and catalyst. To best of our knowledge, this is first report for the synthesis of β-amino carbonyl compounds over MgO/ZrO2
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