Abstract
We developed one-pot photoreduction strategy to prepare near infrared light (NIR)-absorbing plasmonic gold nanoparticles (Au NPs) tethered by amphiphilic polypeptide copolymer poly(l-cysteine)-b-poly(ethylene oxide) (PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700–1100nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation (808nm, 2W/cm2, 5min), the PLC-b-PEO@Au NPs (1mg/mL) sharply attained an elevation of 30.8°C and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin (DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy (CT) or photothermal therapy (PT), demonstrating a synergistic effect.
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