Abstract
AbstractA novel domino oxidative Passerini three‐component reaction (OP‐3CR) has been successfully developed with either primary or secondary alcohols instead of their corresponding aldehydes or ketones by using a recyclable magnetic core‐shell nanoparticle supported TEMPO (2,2,6,6‐tetramethyl‐piperidin‐1‐oxyl) (MNST, 1). It has been shown that MNST is a highly effective and recyclable catalyst system in the metal‐ and halogen‐free aerobic, oxidative, three‐component Passerini reaction. To the best of our knowledge this method can be considered as the first example of a OP‐3CR of alcohols under metal‐ and halogen‐free reaction conditions. It should be also noted that there has been no precedent example of oxidative OP‐3CR of secondary alcohols to their corresponding α‐acyloxy carboxamides. The catalyst can be magnetically recycled and successfully reused in 14 subsequent reaction cycles with only slight decreases of its catalytic activity.
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