Abstract
Starting from different ketones 1a-1f , aldehyde 2a-2g , and acetonitriles 3a-3d we synthesize some bioactive β- Acetamido carbonyl compounds 4a-4h . We also attempted to synthesize these compounds by using phenylacetone and deoxybenzoins in place of ketones to afford the products 4i-4j . 1 H-NMR spectra are presented. On the basis of QSAR studies, some compounds were tested for their anti-thrombotic activity in mice. Compound 4f , 4h and 4j were found to exhibit less percentage protection.
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