Abstract
The photoactivatable CO‐releasing molecule (photoCORM) [Mo(CO)3(CNCH2COOH)3] (ALF795) has been incorporated into a Zn,Al layered double hydroxide (LDH) host by a coprecipitation synthesis strategy. Powder X‐ray diffraction (PXRD) of the resultant material Zn,Al‐ALF795 showed that the ALF795 guest molecules assembled into a monolayer to give a basal spacing of 16.0 Å. FTIR and 13C{1H} CP MAS NMR spectroscopy confirmed that the molecular structure of the tricarbonyl complex was retained upon intercalation. Scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDS) and elemental analyses confirmed the phase‐purity of Zn,Al‐ALF795. The myoglobin assay was used to demonstrate that intercalated ALF795 retains the photoactive behavior of the free CORM, with a substantial fraction (42 %) of the high CO payload (2.46 mmol g–1) being released after exposure to UV light for 3 h under simulated physiological conditions. In addition, gas chromatography was used to track sequential light‐ and H2O2‐triggered decarbonylation of free and intercalated ALF795. In biological buffer solution (HEPES), less than 2 % Mo leaching from Zn,Al‐ALF795 took place after 5 h, showing the strong capacity of the LDH host to retain the unaltered complex and decarbonylation fragments.
Highlights
Carbon monoxide is a poisonous gas that cannot be seen, smelled or tasted
We demonstrated that layered double hydroxides can be used as a carrier system for the photoCORM [Mo(CO)3(CNCH2COOH)3] (ALF795)
A few examples of metal carbonyl-intercalated layered double hydroxide (LDH) have been reported previously, this is the first case where such a material has been studied from the COreleasing molecules (CORMs) perspective
Summary
Carbon monoxide is a poisonous gas that cannot be seen, smelled or tasted. Prolonged exposure or acute exposure to high concentrations of CO can cause serious illness, coma and death.[1]. Romão Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, EAN, 2780-157, Oeiras, Portugal enough to ensure efficient cytoprotection. These innate immune defenses may be enhanced by administration of exogenous CO and this has been explored in multiple clinical trials that use gas inhalation as the delivery method.[5] CO has tremendous therapeutic potential in ailments such as rheumatoid arthritis, gastric ulcers, sepsis, lung injury, cardiovascular disease, stroke, transplant rejection, and cancer.[6,7,8]
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