One pot facile visible-light promoted synthesis of quinazolinones via Csp3-H oxidation in aqueous media

Abstract

The utilization of biocompatible catalysts for the synthesis of biologically significant molecules in aqueous environments represents a pivotal and challenging aspect within the realm of green and sustainable chemistry. Herein, a KI-mediated Csp3-H oxidation reaction to synthesis heterogeneously of quinazolinones is reported in this study. Aldehydes, formed from the oxidation of alcohols, undergo amide attacks and subsequent cyclization, efficiently producing a variety of quinazolinones under sunlight and in aqueous media. The utilization of solar energy significantly reduces experimental costs and minimizes the occurrence of toxic effects. This approach proceeded smoothly to afford quniazolinones in high to excellent yields with a wide substrate scope.