One‐Pot Double Cyclizations Involving an Aza‐Prins Process

Abstract

Piperidine derivatives are highly abundant in natural products and pharmaceutically relevant compounds. Aza‐Prins cyclization has emerged as a step‐ atom‐economical and stereoselective method for the preparation of such azacycles. The possibility of coupling aza‐Prins process with the formation of a second cycle in a one‐pot manner is even more powerful and makes the object of this review. Cascade/domino/tandem bis‐cyclizations involving an aza‐Prins process, for the rapid construction of complex small molecules, are discussed in detail.