One-pot copper nanoparticle-catalyzed synthesis of imidazo[1,2-a]pyridines under solvent-free conditions

Abstract

A direct and efficient approach to synthesize imidazo[1,2-a]pyridines through three-component one-pot reaction of 2-aminopyridine, aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed. This method provides a rapid access to substituted imidazo[1,2-a]pyridines with good yields(up to 85%).