Abstract
A ‘two birds, one stone’ strategy was developed via a one-pot click reaction to simultaneously prepare a novel cyclodextrin (CD) dimer based aggregation induced emission (AIE) sensor (AIE-DCD) and a monomer based chiral stationary phase (CSP-MCD) for chiral high performance liquid chromatography (CHPLC). AIE-DCD was found to afford satisfactory AIE response for specific detection of Zn2+ with a detection limit of 50 nM. CSP-MCD exhibits excellent enantioseparation ability toward dansyl amino acids, where the resolution of dansyl amino leucine reaches 5.43.
Highlights
Cyclodextrins (CDs) are known to embody a unique hydrophobic cavity which is able to encapsulate different kinds of guest molecules and a hydrophilic surface originating from the hydroxyl moieties on the rims [1,2,3]
(TPE) is is aa typical typical fluorophore and easy modification; fluorophore which which processes processes the the advantages advantages of of facile facile synthesis synthesis and easy structural structural modification; numerous functional groups groups can canbe beattached attachedtotoit itthrough throughsimple simple reactions, it was chosen as numerous functional reactions, so so it was chosen as the the fluorescence in this study
To further approve the effectiveness of the one-pot click approach, we firstly evaluated the aggregation induced emission (AIE)
Summary
Cyclodextrins (CDs) are known to embody a unique hydrophobic cavity which is able to encapsulate different kinds of guest molecules and a hydrophilic surface originating from the hydroxyl moieties on the rims [1,2,3]. Considering our previous efforts in the preparation of CD-CSPs, it is possible that the N3 -CD residue in the crude product of AIE-CDs can be removed by subsequent click reaction with alkyne functionalized silica to afford triazole-bridged CD-CSP as a by-product. With this idea, in this work, we would like to develop a ‘one-pot’ click procedure to obtain two structurally well-defined functional. As far as we know, there are very few reports describing the ‘two birds, one stone’ strategy for the preparation of structurally well-defined CD materials This approach is believed to provide a facile way to obtain novel CD derivatives and solid-based CD materials with a well-defined structure [27,28]
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