One-Pot Cascade Michael-Cyclization Reactions of o-Hydroxycinnamaldehydes: Synthesis of Functionalized 2,3-Dihydrobenzofuranes

Abstract

However, these methods cannot begeneralized as much as is desirable, and they yielded poorchemo- and/or stereoselectivities. Hence, the developmentof an efficient enantioselective synthetic method for obtain-ing 2,3-dihydrobenzofuran scaffolds attracted our attention.As part of the research program related to the developmentof synthetic methods for the enantioselective construction ofstereogenic carbon centers, we recently developed a novelcatalytic asymmetric 1,4-addition reaction of o-hydroxy-cinnamaldehydes using organocatalyst, which affordedenantio-enriched chroman derivatives.