One-Pot and Three-Component synthesis of Substituted Pyrimidines Catalysed by Boron Sulfuric Acid under Solvent-Free Conditions

Abstract

An efficient, simple and one-pot synthesis of pyrimidine derivatives by a three-component reaction of ketones, triethyl orthoformate, and ammonium acetate in the presence of boron sulfuric acid as a reusable and efficient catalyst under solvent-free conditions is reported. The reusability of catalyst, simplicity of the starting materials, short reaction time, one-pot, and good yields of products are the main advantages.