One-pot access to l-5,6-dihalotryptophans and l-alknyltryptophans using tryptophan synthase

Abstract

We report, for the first time, the use of tryptophan synthase in the generation of L-dihalotryptophans and l-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.