One of North Carolina’s Largest Philanthropies Supports and Listens to HIV/AIDS Service Providers

Abstract

**BACKGROUND AND PURPOSE:** A rapid and accurate MR imaging technique would be beneficial to assess paragangliomas in the head and neck and to distinguish them from other lesions. The purpose of this study was to determine whether the combination of elliptic centric contrast-enhanced MR angiography (CE-MRA) and unenhanced and enhanced spin-echo imaging (conventional MR imaging) is more accurate than conventional MR imaging alone to assess paragangliomas in the head and neck. **MATERIALS AND METHODS:** Three radiologists retrospectively and independently reviewed CE-MRA and conventional MR imaging in 27 patients with suspected paragangliomas. The overall image quality and the probability of paraganglioma were recorded. The results of each technique and their combination were analyzed for sensitivity and specificity. Receiver operating characteristic (ROC) analyses were performed by using histologic analysis, imaging, and/or clinical findings as the reference standard. **RESULTS:** Forty-six lesions were found in 27 patients. In the assessment of paragangliomas, the combination of conventional MR imaging and CE-MRA was significantly superior to conventional MR imaging alone. Sensitivity and specificity respectively were the following: for CE-MRA, 100% and 94%; and for conventional MR imaging, 94% and 41%. The specificity of CE-MRA was significantly higher than that of conventional MR imaging (*P* = .004). There was good-to-excellent interobserver agreement for the paraganglioma probability with CE-MRA (nonweighted κ, 0.67--0.77), whereas there was fair-to-good interobserver agreement with conventional MR imaging (nonweighted κ, 0.50--0.65). **CONCLUSION:** In combination with conventional MR imaging, CE-MRA yields an excellent diagnostic value for the assessment of head and neck paragangliomas; hence, the 2 techniques should be regarded as complementary.