One New Steroidal Saponin from the Leaves of Cordyline fruticosa (L.) A. Chev.

Abstract

: The aim of this study is to isolate and identify new chemical constituents from Cordyline fruticosa (L.) A. Chev. growing in Vietnam. Cordyline fruticosa (L.) A. Chev. (Synonym: Cordyline terminalis L. Kunth), belongs to the Asparagaceae family, is one of the popular plants in folk medicine. This plant has been used to treat various diseases, such as sore throat, neck pain, bloody urine, kidney diseases, headache, infections of mammary glands, and inflammation in the digestive tract. Previous study on the leaves of C. fruticosa (L.) A. Chev. reported the presence of cholestane glycosides with cytotoxic activity. The leaves of Cordyline fruticosa (L.) A. Chev. were provided by a flower shop in Thai Nguyen city, Vietnam in 2021 (21°35'53" N, 105°50'17" E). The extraction was performed by the ultrasound-assisted method using the solvent EtOH/H2O. The crude extract was chromatographed on silica gel to yield one compound. The structure elucidation of isolated compound was determined by spectroscopic analysis 1D and 2D NMR, and mass spectroscopy (HR-ESI-MS in positive mode). A new steroidal saponin was isolated from the leaves of Cordyline fruticosa (L.) A. Chev. The structure of compound was determined as 26-O-β-D-glucopyranosyl-furosta-5,(25)27- diene-1β,3β,22α,26-tetrol-1-O-β-D-glucopyranoside. Phytochemical study on the leaves of Cordyline fruticosa (L.) A. Chev. lead to the isolation and elucidation of one new steroidal saponin. Previous investigation on species of Cordyline genus revealed the presence of steroidal saponins, so this study has a significant benefit to complete the chemotaxonomic data about saponins from genus Cordyline and thus Asparagaceae family. The biological test of this compound should be further carried out in the next study.