One new α-pyrone and one new fatty acid derivative from mangrove-derived fungus Phomopsis sp. HYP11

Abstract

One new α -pyrone derivative ( S )-3-(4-methoxy-3-methyl-2-oxo-2 H -pyran-6-yl)butyl acetate ( 1 ) and one new fatty acid derivative (4 S ,5 S )-5-acetoxy-4-hydroxyhexanoic acid ( 2 ), along with six known compounds ( 3–8 ) were obtained from the mangrove-derived fungus Phomopsis sp. HYP11. Their structures and absolute configurations were determined by detailed 1D and 2 D NMR, HR-ESI-MS spectral, and quantum chemical electronic circular dichroism (ECD) calculations. Compounds 2 , 3 , 5 , 6 and 8 showed antioxidant activity with the IC 50 values range of 0.09–0.67 mM, especially compounds 5 and 6 showed stronger antioxidant activity than the positive control trolox (IC 50 = 0.29 mM). Compound 8 showed weak antagonistic effect on Ralstonia solanacearum with the MIC value of 50 μg/mL. • One new α -pyrone derivative and one new fatty acid derivative were isolated and characterized. • Compounds 2 , 3 , 5, 6 and 8 showed antioxidant activity with the IC 50 values range of 0.09–0.67 mM. • Compounds 5 and 6 showed stronger antioxidant activity than the positive control (IC 50 = 0.29 mM).