One new 2-(2-Phenylethyl)chromone Derivative from Agarwood of Aquilaria crassna in Cambodia

Abstract

One new 2-(2-phenylethyl)chromone (1), three new naturally occurring 2-(2-phenylethenyl)chromones (3–5), together with a known 2-(2-phenylethyl)chromone (2) were isolated from the EtOH extract of agarwood originating from Aquilaria crassna in Cambodia. Their structures were unambiguously elucidated by detailed spectroscopic (NMR, UV, IR, MS) analyses. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxicity against tumor cell lines (K562, BEL-7402, SGC-7901 and Hela). Compound 1 displayed weak AChE inhibitory activity (inhibitory ratio: 35.0 ± 2.19%) and cytotoxicity against K562 tumor cell line (IC50: 40.81 ± 0.64 μM). Along with, compound 3 showed cytotoxicity against BEL-7402 tumor cell line (IC50: 44.18 ± 0.34 μM).