Abstract
Gold nanoparticles (AuNPs) are one of the most studied nanosystems with great potential for biomedical applications, including cancer therapy. Although some gold-based systems have been described, the use of green and faster methods that allow the control of their properties is of prime importance. Thus, the present study reports a one-minute microwave-assisted synthesis of fucoidan-coated AuNPs with controllable size and high antitumoral activity. The NPs were synthesized using a fucoidan-enriched fraction extracted from Fucus vesiculosus, as the reducing and capping agent. The ensuing monodispersed and spherical NPs exhibit tiny diameters between 5.8 and 13.4 nm for concentrations of fucoidan between 0.5 and 0.05% (w/v), respectively, as excellent colloidal stability in distinct solutions and culture media. Furthermore, the NPs present antitumoral activity against three human tumor cell lines (MNT-1, HepG2, and MG-63), and flow cytometry in combination with dark-field imaging confirmed the cellular uptake of NPs by MG-63 cell line.
Highlights
Cancer, i.e., the abnormal growth and proliferation of cells, is one of the leading causes of mortality and morbidity worldwide
The fucoidan-assisted synthesis of fucoidan-coated gold nanoparticles (AuNPs) were synthesized, using a fucoidan-enriched fraction extracted from F. vesiculosus, and characterized in terms of structure, colloidal stability, antitumoral activity against different cell lines (MNT-1, HepG2, and MG-63), and cellular uptake by flow cytometry and dark field imaging of
The one-minute microwave-assisted synthesis of fucoidan-coated gold nanoparticles (AuNPs) with controllable, high stability, and antitumoral activity is the first and foremost contribution of the present study, where fucoidan-AuNPs were synthesized by using a fucoidan-enriched fraction extracted from F. vesiculosus, as simultaneous reducing and capping agent
Summary
I.e., the abnormal growth and proliferation of cells, is one of the leading causes of mortality and morbidity worldwide. According to the World Health Organization (WHO), cancer was responsible for 9.9 million deaths in 2018 [1], and the number of cases is anticipated to increase by about. Each cancer type involves a specific treatment procedure that embraces one or more modalities, namely surgery (to remove the tumor), radiotherapy, or chemotherapy. Despite the high cure rates observed when cancer is detected early and if appropriated treatment is provided, most of the presently employed therapies, conventional chemotherapy, are associated with severe side effects, including hair loss, nausea and vomiting, pain, anemia, fertility issues, edema, among many others [2], that strongly affect the patient’s quality of life. The design of more effective alternatives that allows a targeting action, with almost no impact on healthy tissues or organs, has received considerable attention [3].
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