Abstract
Novel nude mice model of human NK/T cell lymphoma were established by subcutaneously injecting two NK/T cell lymphoma cell lines into the right axillary region of mice and successful passages were completed by injecting cell suspension which was obtained through a 70‐μm cell strainer. These mice models and corresponding cell clones have been successfully developed for more than 8 generations. The survival rates of both resuscitation and transplantation in NKYS and YT models were 90% and 70% correspondingly. Pathologically, the tumour cells in all passages of the lymphoma‐bearing mice and cell lines obtained from tumours were parallel to initial cell lines. Immunologically, the tumour cells expressed the characteristics of the primary and essential NK/T lymphomas. The novel mice models maintained the essential features of human NK/T cell lymphoma, and they would be ideal tools in vivo for further research of human NK/T cell lymphoma.
Highlights
Extranodal natural killer (NK)/T cell lymphoma (ENKTCL) is an aggressive malignancy of putative NK cell origin, with a minority deriving from the T cell lineage
The malignancy occurs in two forms, extranodal NK/T cell lymphoma, nasal type (NNKTCL); and aggressive NK cell leukaemia.[1]
There is a growing need for mouse models that have stable characteristics to mimic in vivo studies of NK/T cell lymphomas
Summary
Extranodal natural killer (NK)/T cell lymphoma (ENKTCL) is an aggressive malignancy of putative NK cell origin, with a minority deriving from the T cell lineage. Passages have various advantages over cell lines in vitro and single mouse models that have no passage in lymphoma research in vivo. It is an efficient in vivo platform to investigate drug efficacy and resistance studies in various cancers, but likely to be applied to lymphoma therapy. There is a growing need for mouse models that have stable characteristics to mimic in vivo studies of NK/T cell lymphomas. We introduce two NK/T cell lymphoma mouse models we have established successfully
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