Abstract
The dosing of antiretrovirals in children living with HIV aims to achieve drug exposures similar to those observed in successfully treated adults and to monitor safety. This aim applies to all diseases in which the exposure–response relationship is expected to be similar in adults and children. 1 Dunne J Rodriguez WJ Murphy MD et al. Extrapolation of adult data and other data in pediatric drug-development programs. Pediatrics. 2011; 128: e1242-e1249 Crossref PubMed Scopus (210) Google Scholar In all cases, the focus of paediatric dose optimisation is primarily to account for the effects of body size and maturation on drug concentrations. 2 Cella M Knibbe C Danhof M Della Pasqua O What is the right dose for children?. Br J Clin Pharmacol. 2010; 70: 597-603 Crossref PubMed Scopus (98) Google Scholar , 3 Holford N Heo Y-A Anderson B A pharmacokinetic standard for babies and adults. J Pharm Sci. 2013; 102: 2941-2952 Summary Full Text Full Text PDF PubMed Scopus (200) Google Scholar
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