Ondansetron versus ramosetron in attenuation of propofol-induced pain during induction of anaesthesia

Abstract

Our main goal is to compare effect of ondansetron and ramosetron in attenuation of propofol-induced pain during induction of anaesthesia. A total of sixty subjects with American Society of Anesthesiologists (ASA) physical status (PS) 1 and 2, age ranging 18-60 years scheduled for various elective surgical procedures under general anaesthesia were included and were randomly divided into 2 groups. Group 1 received 4 mg of ondansetron and Group II received 0.3 mg of ramosetron. Mean age of patients in group 1 was 36.2 years and in group 2 was 36.0 years. There were 16 males and 14 females in group 1 and 17 males and 13 females in group 2. ASA grade I was seen in 20 in group 1 and 24 in group 2 and ASA grade II was seen in 10 in group 1 and 6 in group 2. A non- significant difference between both groups was seen (P> 0.05). Pain score 0 was observed in 14 in group 1 and 20 in group 2, score 1 in 9 in group 1 and 6 in group 2, score 2 in 4 in group 1 and 3 in group 2 and score 3 seen in 3 in group 1 and 1 in group 2. A significant difference between both groups was seen (P< 0.05). Ramosetron alone can be used to reduce the propofol-induced pain. Pre-treatment with IV ramosetron found to be effective as compared to ondansetron in preventing propofol-induced pain.