Abstract
Aim: To determine the efficacy of single dose ondansetron in preventing PONV in patients.
 Methodology: In this cross sectional study 49 patients were given Ondansetron. Every patient was evaluated for PONV at 1, 2, 3, 6, 12 and 24 hours post operatively. This study was conducted at General surgery operation theatres and surgical wards I, II, III and Department of Anesthesia and SICU Peoples University of Medical & Health Sciences for women Nawabshah, District Shaheed Benazirabad, Sindh.
 Results: A sample of 49 patients with age between 20-60 years (mean age 43.72±5.67 years), 35% male and 65% female was included in this study. In this study ondansetron was given (N=49) 4 mg I/V before induction. Regarding complications there was not significant (p ≤0.05) POVN was observed.
 Conclusion: Our study results showed in patients who received ondansetron regarding frequency of post operative complications (PONV) showed insignificant results as no p-value is found to be ≤0.05.It was concluded that a single dose of ondansetron is very effective in preventing PONV in general surgery patients.
Highlights
Nausea and vomiting are most common postoperative complications and occur after local, regional and general anesthesia
The laparoscopic surgeries are related with considerably high rate of Postoperative Nausea and Vomiting (PONV) [2] due to creation of pneumoperitoneum during the procedure [4]
This cross sectional study was conducted at General surgery operation theatres and surgical wards I, II, III and Department of Anaesthesia and SICU Peoples University of Medical & Health
Summary
Nausea and vomiting are most common postoperative complications and occur after local, regional and general anesthesia. In anesthetic practice several drugs e.g ketorolac, ondansetron, buprenophine, propofol and techniques Postoperative Nausea and Vomiting (PONV) are among the common stressful complications of surgery and anesthesia [3]. The laparoscopic surgeries are related with considerably high rate of PONV [2] due to creation of pneumoperitoneum during the procedure [4]. In high risk groups the incidence still remained around 80% despite use of modern anesthetic practices [5]. A considerable proportion of patient experience PONV despite the widespread use of prophylactic antiemetics, including 5HT3receptor antagonists [8,9]
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