Abstract
The budding yeast ( Saccharomyces cerevisiae ) gene deletion library consists of a collection of more than 6,000 gene-deletion mutants and is useful for high-throughput screening of anti-cancer drugs. Because of the shorter doubling time and the significant homology the budding yeast shares with human cells, using a high-throughput chemical screen of budding yeast gene deletion library, one can rapidly identify various genetic targets of anti-cancer drugs. But analyzing the data derived from a yeast library screen to identify corresponding human homologs and their status in various cancers is a cumbersome process. We have developed a web-based app, Oncoyeasti , which enables the researcher to automatically identify the corresponding human homologs of S. cerevisiae and the status of these homologs genes in tumor samples from The Cancer Genome Atlas Database and cell line samples from the Cancer Cell Line Encyclopedia. This would enable the scientists to identify the tumors and choose cell lines to work on and thus serve as an indispensable tool to translate their research into human cancers.
Highlights
Cancer chemotherapies, the backbone of cancer, treatment have multiple shortcomings including significant toxicities, narrow therapeutic indexes, and the emergence of resistance
Imatinib is commonly used for the treatment of the chronic myeloid leukemia (CML), targeting fusion protein BCR-ABL, and in the treatment of gastrointestinal stromal tumors (GIST) that harbor cKIT and PDGFRA mutations[3,4,5]
We have developed a web-based application, Oncoyeasti, that matches genes S. cerevisiae genes with corresponding human homologs and browses through the The Cancer Genome Atlas (TCGA) and cBioPortal database to show the status of these matched human homolog genes in various cancers
Summary
Atlas Database and cell line samples from the Cancer Cell Line Encyclopedia. This would enable the scientists to identify the tumors and choose cell lines to work on and serve as an indispensable tool to translate their research into human cancers. Cancer, drug screening, toxicity screen, human homologs, cancer cell lines, TCGA, CCLE, translational research.
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