Oncoplastic Surgery and the Clinical Features of Breast Cancer-Relevant Factors Associated with Reoperation in Breast Oncoplastic Surgery.

Andrzej Stanisławek,Robert Sitarz,Jacek Baj,Sergiusz Łukasiewicz,Krzysztof Sołowiej,Alicja Forma

doi:10.3390/jcm11030817

Andrzej Stanisławek, Robert Sitarz + Show 4 more

Open Access

https://doi.org/10.3390/jcm11030817

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Abstract

Oncoplastic breast surgery slowly becomes a part of routine breast cancer surgical management but evidence with regard to oncological safety remains limited. The aim of this study was to compare relevant factors associated with the particular type of breast carcinoma and the applied surgical techniques either with or without oncoplastic surgery. This retrospective study enrolled the breast cancer female patients who underwent breast-conserving therapy alone or with the oncoplastic surgery in the Department of Surgical Oncology at the Center of Oncology of the Lublin Region St. Jana from Dukli in the years 2008–2011. The study involves 679 breast cancer patients who underwent oncoplasty (n = 81) and the control group (n = 598). There is a significant relationship between the histological type of breast cancer (p = 0.00000) along with the expression of estrogen and/or progesterone receptors (p = 0.01285) and the usage of oncoplastic surgery in breast cancer patients. Interestingly, in the majority of cases, there was no need to conduct a reoperation. Oncoplastic surgery is an effective and safe strategy that might be favorable especially for those patients who are potential candidates for more invasive surgical methods. High-quality evidence to support the oncological safety and benefits of oncoplastic breast surgery is lacking.

Highlights

Breast cancer is the most prevalent cancer among females, being responsible for more than 1.5 million new diagnoses per year, and the incidence rate is still increasing [1]
There are several treatment strategies as well as surgical techniques for breast cancer patients, and the choice of the most convenient method primarily depends on the size and location of the tumor; other aspects such as the size of the breast or the personal wishes of the patient are taken into consideration
Even though several breast-conserving surgical procedures such as partial mastectomy, tumorectomy, or lumpectomy seem to be beneficial for patients due to their limited and effective surgical approach, the aesthetic values remain unsatisfactory to some extent

Summary

Introduction

Breast cancer is the most prevalent cancer among females, being responsible for more than 1.5 million new diagnoses per year, and the incidence rate is still increasing [1]. Breast cancer is considered to be the second leading cause of cancer-related deaths in women [2]. The classification of both the histological and molecular types of breast cancer depends on several pathological and clinical features. The major histological classification includes such types as invasive ductal carcinoma (the highest prevalence rate) [3], lobular carcinoma, medullary carcinoma, cribriform carcinoma, mucinous carcinoma, oncocytic carcinoma, neuroendocrine carcinoma, or apocrine carcinoma, while the number is continually increasing because of different combinations of the pathological features shared between the above-mentioned conditions [4]. Even though several breast-conserving surgical procedures such as partial mastectomy, tumorectomy, or lumpectomy seem to be beneficial for patients due to their limited and effective surgical approach, the aesthetic values remain unsatisfactory to some extent

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