Abstract
Buschke-Löwenstein tumor (BLT) is a rare but impressive and aggressive entity and is mostly associated with Human Papilloma Virus (HPV) 6 or 11 infection in immunocompromised patients. It stands out because of the importance of the recurrences and the risk of progression to a malignant tumor. The first-line treatment remains local radical surgery. Other treatments are controversial, including radiotherapy, chemotherapy, and immunotherapy. We report a new case regarding the management of a giant BLT in a non-immunocompromised woman, treated in a three-staged approach, starting with a radical excisional surgery, followed by a delayed reconstruction and then radiotherapy.
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