Abstract
sBackgroundPrimary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment. The goal of the current study was to analyse the potential prognostic factors and clinical outcomes for this tumour type.MethodsConsecutive patients with surgically treated primary parotid SCC were retrospectively enrolled in this study. The primary end point was locoregional control (LRC) and disease-specific survival (DSS), which were calculated by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method.ResultsIn total, 53 patients were included for analysis. Perineural and lymphovascular invasion were observed in 21 and 16 patients, respectively. Intraparotid node (IPN) metastasis was reported in 23 patients with an incidence rate of 43.3%. Twenty-six patients with cN0 disease underwent neck dissection, and pathologic node metastasis was observed in 10 cases. The 5-year LRC and DS S rates were 35 and 49%, respectively. The Cox model was used to report the independence of disease stage and IPN metastasis in predicting LRC and the independence of disease stage and perineural invasion in predicting DSS.ConclusionsThe prognosis of primary parotid SCC is relatively unfavourable. IPN metastasis significantly decreases disease control, disease stage is the most important prognostic factor, and neck dissection is suggested for patients at any stage.
Highlights
Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment
Intraparotid node (IPN) metastasis was reported in 23 patients with an incidence rate of 43.3%
The Cox model was used to report the independence of disease stage and IPN metastasis in predicting locoregional control (LRC) and the independence of disease stage and perineural invasion in predicting disease-specific survival (DSS)
Summary
Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment. The goal of the current study was to analyse the potential prognostic factors and clinical outcomes for this tumour type. Parotid cancers account for 70% of all salivary gland malignancies, and there are 24 different types of malignancies [1,2,3], of which squamous cell carcinoma (SCC) is one of the least common histologic subtypes. Owing to the extreme rarity of parotid SCC, very few authors have focused on this cancer [4,5,6,7,8,9,10,11,12,13,14]. Fang et al BMC Cancer (2019) 19:752 the present study aimed to analyse the potential prognostic factors and clinical outcomes of this disease
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