Abstract
IntroductionTumor-induced osteomalacia is a paraneoplastic syndrome of hypophosphatemia. Osteomalacia causes multiple bone fractures and severe pain.Case presentationWe report the case of a 57-year-old Japanese man with tumor-induced osteomalacia associated with a middle cranial fossa bone tumor. The tumor was successfully resected by using a middle fossa epidural approach. His phosphate level recovered to a normal range immediately after the surgery.ConclusionsIt is rare that tumor-induced osteomalacia originates from the middle skull base. This report suggests that, if patients have a clinical and biochemical picture suggestive of tumor-induced osteomalacia, it is crucial to perform a meticulous examination to detect the tumor or the lesion responsible for the tumor. The serum level of fibroblast growth factor 23 is the most reliable marker for evaluating the treatment outcome of tumor-induced osteomalacia.
Highlights
Tumor-induced osteomalacia is a paraneoplastic syndrome of hypophosphatemia
It is rare that tumor-induced osteomalacia originates from the middle skull base
We report a case of tumor-induced osteomalacia associated with a middle fossa bone tumor
Summary
We treated a case of hypophosphatemia associated with tumor-induced osteomalacia. For patients who have a clinical and biochemical profile suggestive of tumor-induced osteomalacia, it is crucial to perform an in-depth examination to detect the tumor or the lesion responsible for the tumor. FGF-23 is the most reliable marker to evaluate the usefulness of any treatment for tumor-induced osteomalacia. Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Competing interests The authors declare that they have no competing interests. Authors’ contributions IC was involved in the diagnosis and treatment of our patient and wrote the manuscript. KI, TG, and KO were involved in the diagnosis of our patient and helped to revise the manuscript. All authors read and approved the final manuscript
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