Oncogenes calling on a lysosomal Ca2+ channel.

Abstract

Oncogene‐dependent cancers upregulate and use lysosomal biogenesis for nutrient supply. It is unclear which lysosomal proteins and functions are essential for cell proliferation and tumor growth. A study by Jung et al in this issue of EMBO Reports shows that increased levels of the lysosomal Ca 2+ release channel TRPML1 and its activator PI(3,5)P 2 in HRAS G 12V ‐dependent tumors are essential for cell proliferation and tumor growth [1]. Notably, genetic and pharmacological inhibition of TRPML1 is equally effective in suppressing HRAS G 12V ‐dependent tumors.