Abstract
The proliferation of normal cells is regulated by the balance between the growth-promoting signals of proto-oncogenes and the growth-constraining signals of tumor suppressor genes [1, 2]. Multiple steps including initiation, promotion and progression are required for the conversion of normal cells to fully malignant cells with invasive and metastatic capacities. Multiple genetic changes, including activation of proto-oncogenes and inactivation of tumor suppressor genes, occurs during multi-step carcinogenesis which takes 20–30 years [3]. Gastric cancer is still one of the most common malignancies, not only in Japan, but also worldwide. Yet, there has been only limited information available on genetic changes in gastric cancer. In this chapter, all the available information on genetic changes in gastric cancer will be presented, and its perspectives will be discussed.
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