Abstract

Hybrids between certain species of the teleost fish Xiphophorus predictably develop melanomas. Classical mendelian crossing experiments have allowed us to identify genetic loci involved in eliciting and suppressing tumorigenesis, and in many cases tumorigenesis seems to result from the elimination of a suppressor gene. The melanomas consist of incompletely differentiated pigment cells and in many aspects resemble their murine and human counterparts.

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