Oncocytic adrenal tumour presenting as Cushing syndrome: rare presentation of a rare tumour

Subodh Banzal,Abhishek Singhai

doi:10.4103/1110-7782.148180

Subodh Banzal, Abhishek Singhai

Open Access

https://doi.org/10.4103/1110-7782.148180

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Abstract

Oncocytic neoplasms are well recognized in organs such as the kidney, thyroid and salivary glands. They are seen rarely in other sites such as the adrenal cortex. To date, around 20 cases of oncocytic adrenocortical neoplasm have been reported; most of them were benign and nonfunctioning. We report the case of hypersecreting adrenocortical oncocytoma in a 52-year-old woman. The patient was tested because of cushingoid features. The patient underwent a laparotomy for right adrenal gland mass. The pathology report confirmed adrenocortical oncocytoma.

Highlights

Hamperi [1] introduced the term ‘oncocyte’ in 1931 referring to a cell with abundant, granular, eosinophilic cytoplasm
Electron microscopic studies revealed that this granularity was due to mitochondria accumulation in the oncocyte cytoplasm [2]
Histologic and immunohistochemical features of oncocytic adrenocortical carcinoma that presented as Cushing syndrome

Summary

Introduction

Hamperi [1] introduced the term ‘oncocyte’ in 1931 referring to a cell with abundant, granular, eosinophilic cytoplasm. Electron microscopic studies revealed that this granularity was due to mitochondria accumulation in the oncocyte cytoplasm [2]. Neoplasms composed predominantly or exclusively of this kind of cells are called ‘oncocytic’. Oncocytic adrenocortical neoplasms are rare, usually nonfunctioning tumours found predominantly in adults.

Results

Conclusion