Abstract
(1) Background: Bisphenol A (BPA) based dental resins are commonly used in preventive and reparative dentistry. Since some monomers may remain unpolymerized in the application of dental resin, they dissolve in the saliva. (2) Methods: The literature search was carried out in Pubmed, Cochrane and Embase databases. Randomized controlled trials, cohort studies and case-control studies that evaluated BPA levels in human urine, saliva and/or blood were included. (3) Results: The initial search had 5111 results. A total of 20 studies were included in the systematic review. Most studies showed an increase of the levels of bisphenol A 1 h after treatments with composite resins and dental sealants. One week after treatments the levels were decreased. (4) Conclusions: Some clinical precautions should be taken to decrease the release of BPA, namely the use of rubber dam, the immediate polishing of all resins used, or the use of glycerin gel to avoid non-polymerization of the last resin layer, and mouthwash after treatment. Another preventive measure in addition to the above-mentioned is the use of the smallest possible number of restorations or sealants, a maximum of four per appointment. These measures are even more important in children, adolescents and pregnant women.
Highlights
Endocrine active substances (EAS)such as Bisphenol A (BPA)(2,2-bis[40 -(20 hydroxy-30 -methacryloxy) phenyl] propane) and BPA-derivatives can cause estrogenic activity, and may affect human health [1,2].This synthetic chemical compound was first synthesized by an acid-catalyzed reaction of phenol and acetone in 1891 [3,4]
Reading the full text led to the exclusion of nine records when submitted to the scrutiny of the exclusion criteria
After reading the articles in full, 20 articles were included for the systematic review
Summary
Endocrine active substances (EAS)such as Bisphenol A (BPA)(2,2-bis[40 -(20 hydroxy-30 -methacryloxy) phenyl] propane) and BPA-derivatives can cause estrogenic activity, and may affect human health [1,2].This synthetic chemical compound was first synthesized by an acid-catalyzed reaction of phenol and acetone in 1891 [3,4]. (2,2-bis[40 -(20 hydroxy-30 -methacryloxy) phenyl] propane) and BPA-derivatives can cause estrogenic activity, and may affect human health [1,2]. This synthetic chemical compound was first synthesized by an acid-catalyzed reaction of phenol and acetone in 1891 [3,4]. BPA is used in the manufacture of many types of products, including polycarbonate plastic and epoxy resin presented in bottles, food packaging, toys, cars, detergents, pesticides and dental resins materials [5,6]. Res. Public Health 2019, 16, 1627; doi:10.3390/ijerph16091627 www.mdpi.com/journal/ijerph
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