Abstract
When nonsteroidal anti-inflammatory drugs (NSAIDs) are used, great attention is paid to their safety now. NSAIDs are primarily evaluated for their effects on the gastrointestinal mucosa, also assess the risk from NSAIDs on liver function. The retrospective analysis of 179 case histories of patients with rheumatoid arthritis, made at the Research Institute of Rheumatology, Russian Academy of Medical Sciences, has revealed no hepatotoxic reactions in the treatment with nise alone and in combination with methotrexate or leflunomide, which are known to be hepatotoxic. There was not more than a 2-fold increase in the level of hepatic enzymes in 7.8 and 10.2% of patients receiving nise and diclofenac, respectively.
Highlights
Once more about the safety of nimesulide R.M
When nonsteroidal anti-inflammatory drugs (NSAIDs) are used, great attention is paid to their safety
NSAIDs are primarily evaluated for their effects on the gastrointestinal mucosa, assess the risk from NSAIDs on liver function
Summary
Once more about the safety of nimesulide R.M. Balabanova, G.G. Koreshkov, O.N. Egorova, M.E. Zapryagayeva Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow The retrospective analysis of 179 case histories of patients with rheumatoid arthritis, made at the Research Institute of Rheumatology, Russian Academy of Medical Sciences, has revealed no hepatotoxic reactions in the treatment with nise alone and in combination with methotrexate or leflunomide, which are known to be hepatotoxic. Минушкиным [7], который оценил его влияние на слизистую ЖКТ у 600 больных, получавших препарат в течение 1–3 мес в дозе 200 мг/сут.
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